Overview

Purpose of the Research Project

The most distinguished characteristic of the mental function in humans is the ability of self-regulation, which is based on language acquisition and social reciprocity. Humans can use self-regulation to regulate their own mind and establish an ego.

This self-regulation is unique to humans. It is realized by the highly developed prefrontal cortex and is established during adolescence. Adolescence is the phase in life when the prefrontal cortex matures and is thus an important period for establishing an ego. An inappropriate maturation of self-regulation among adolescents, on the other hand, could lead to the prevalence of serious mental health problems in modern society.

This study aims to establish a new interdisciplinary science by investigating the self-regulation mechanism among adolescents and developing a support strategy.

The Research Project

Collaboration Scheme
Figure 1. The Research Strategy

The study involves three stages: A01-investigating the developmental process of self-regulation in adolescence by studying a teen cohort; A02-investigating neural mechanisms of self-regulation development in adolescence using comparative cognitive sciences; and A03-developing a support and intervention strategy through molecular, neural modulation, and psychosocial approaches.

Implications and Scientific Significance

The results of the study on the teen cohort will contribute to society by providing evidence supporting education for adolescents and developing real-world strategies for supporting self-regulation maturation among adolescents. Through intensive collaboration of various scientific fields, we will overcome challenges previously faced in establishing an interdisciplinary human science.

Key Words

Adolescence: the life stage relatively unique to humans, where the prefrontal cortex matures and ego is established.
Self-regulation: The most distinguished characteristic of the mental function in humans, it enables the regulation of the human mind and helps in the establishment of an ego.

Research Organization/Members

Principal investigator

Kiyoto Kasai The University of Tokyo Graduate School of Medicine Psychiatry Neuroimaging

International Advisory Board

Marcus Richards Marcus Richards MRC Unit for Lifelong Health and Ageing, MRC
National Survey for Health and Development, Medical Research Council
Cognitive Epidemiology
Louise Arseneault Louise Arseneault Institute of Psychiatry, King's College, The University of London Biomedical Science, developmental psychology and epidemiology
Elaine F. Walker Elaine F. Walker Samuel Candler Dobbs Professor of Psychology and Neuroscience
Department of Psychology, Emory University
Psychology, Neuroscience
Nicholas B. Allen Nicholas B. Allen Ann Swindells Professor of Clinical Psychology
Department of Psychology
University of Oregon
Clinical psychology, Cinical Neuropsychology
Iroise Dumontheil Iroise Dumontheil Department of Psychological Sciences, Birkbeck, University of London
Institute of Cognitive Neuroscience, University College London
Neuroimaging
George Patton George Patton Centre for Adolescent, University of Melbourne Epidemiology, Adolescent Health
Russell Viner Russell Viner Adolescent Health, Institute of Child Health, Faculty of Population Health Sciences, University College London Global Health, Adolescent Health
Johan Ormel Johan Ormel Department of Psychiatry, University Medical Center Groningen, University of Groningen Psychiatric Epidemiology
Noriko Cable Noriko Cable International Centre for Life course Studies in Society and Health, Department of Epidemiology and Public Health, University College London Epidemiology and Public Health
Tomas Paus Tomas Paus Professor of Psychology and Psychiatry, University of Toronto, Rotman Research Institute, Child Mind Institute Population neuroscience, Psychiatry
Seung-Tak Cheng Sheung-Tak Cheng Chair Professor of Psychology and Gerontology, The Education University of Hong Kong Community Psychology

Evaluation Committee members

Toshio Yamagishi Hokkaido University Social Psychology
Toshikazu Hasegawa The University of Tokyo Behavioral Ecology
Yukihiro Nobuhara The University of Tokyo Philosophy of Sciencej, Neuroethics
Masanobu Kano The University of Tokyo Neurophysiology
Teruhiko Higuchi National Center of Neurology and Psychiatry Psychiatry
Nobumasa Kato Showa University Child Psychiatry

X00 Steering Committee members

Project Leader

Kiyoto Kasai The University of Tokyo Graduate School of Medicine Psychiatry Neuroimaging

Co-project leaders

Mariko Hasegawa Graduate University for Advanced Studies School of Advanced Sciences Evolutional Psychology
Taiki Takahashi Hokkaido University Graduate School of Letters Neuro-economics
Atsushi Nishida Tokyo Metropolitan Institute of Medical Science Department of Psychiatry and Behavioral Science Mental Health, Epidemiology
Tsukasa Sasaki The University of Tokyo Graduate School of Education School Mental Health, Education
Naotaka Fujii Brain Science Institute, RIKEN Laboratory for Adaptive Intelligence Neuroscience
Hiroko Hagiwara Tokyo Metropolitan University Graduate school of Humanities Linguistics, Cognitive Neuroscience of Language
Ryu-ichiro Hashimoto Showa University School of Medicine Neuroimaging
Hiromu Sakai Hiroshima University Graduate school of Education Psycholinguistics
Masato Fukuda Gunma University Graduate School of Medicine Psychiatry, Neuroimaging
Kazuo Okanoya The University of Tokyo Graduate School of Arts and Science Neuroethology
Syudo Yamasaki The University of Tokyo Graduate School of Medicine Clinical Psychology
Shigeto Yamawaki Hiroshima University Graduate School of Biomedical Sciences Psychopharmacology
Toshiya Murai Kyoto University Graduate School of Medicine Psychiatry, Social Neuroscience
Satoshi Tanaka Nagoya University Graduate School of Medicine Psychiatry Psychiatry

A01 Developmental Process of Self-Regulation

Project Leader

Mariko Hasegawa Graduate University for Advanced Studies School of Advanced Sciences Evolutional Psychology

Co-project leaders

Taiki Takahashi Hokkaido University Graduate School of Letters Neuro-economics
Atsushi Nishida Tokyo Metropolitan Institute of Medical Science Department of Psychiatry and Behavioral Science Mental Health, Epidemiology
Tsukasa Sasaki The University of Tokyo Graduate School of Education School Mental Health,  Education

Co-Researchers

Yuji Okazaki Tokyo Metropolitan Institute of Medical Science Department of Psychiatry and Behavioral Science Psychiatry, Genome Medicine
Tadafumi Kato Brain Science Institute, RIKEN Laboratory for Molecular Dynamics of Mental Disorders Molecular Neuroscience
Takaoki Kasahara Brain Science Institute, RIKEN Laboratory for Molecular Dynamics of Mental Disorders Molecular Neuroscience

A02 Neural Mechanism of Self-Regulation

Project Leader

Naotaka Fujii Brain Science Institute, RIKEN Laboratory for Adaptive Intelligence Neuroscience

Co-project leaders

Hiroko Hagiwara Tokyo Metropolitan University Graduate school of Humanities Linguistics, Cognitive Neuroscience of Language
Ryu-ichiro Hashimoto Showa University School of Medicine Neuroimaging
Hiromu Sakai Hiroshima University Graduate school of Education Psycholinguistics
Masato Fukuda Gunma University Graduate School of Medicine Psychiatry, Neuroimaging
Kazuo Okanoya The University of Tokyo Graduate School of Arts and Science Neuroethology

Co-Researchers

Fumitaka Homae Tokyo Metropolitan University Graduate school of Humanities Cognitive Neuroscience, Developmental Brain Science
Kazuya Iwamoto The University of Tokyo Graduate School of Medicine Molecular Neuroscience
Miki Bundo The University of Tokyo Graduate School of Medicine Molecular Neuroscience

A03 Support and Intervention for Self-Regulation

Project Leader

Kiyoto Kasai The University of Tokyo Graduate School of Medicine Psychiatry, Neuroimaging

Co-project leaders

Syudo Yamasaki The University of Tokyo Graduate School of Medicine Clinical Psychology
Toshiya Murai Kyoto University Graduate School of Medicine Psychiatry, Social Neuroscience
Satoshi Tanaka Nagoya University Graduate School of Medicine Nagoya University Hospital Psychiatry
Yasumasa Okamoto Hiroshima University Graduate School of Biomedical Sciences Psychiatry, Cognitive Behavioral Therapy

Co-Researchers

Noriaki Yahata The University of Tokyo Graduate School of Medicine Neuroimaging
Ryu Takizawa The University of Tokyo Graduate School of Medicine Psychiatry, Neuroimaging
Takuma Ishigaki The University of Tokyo Graduate School of Arts and Science Clinical Psychology
Shigeru Morinobu Hiroshima University Graduate School of Biomedical Sciences Molecular Psychopharmacology
Minoru Takebayashi National Hospital Organization Kure Medical Center Psychopharmacology
Jun Miyata Kyoto University Graduate School of Medicine Psychiatry, Correctional Medicine
Hiroki Fukui National Center of Neurology and Psychiatry National Institute of Mental Health Forensic Psychiatry
Norio Ozaki Nagoya University Graduate School of Medicine Psychiatry, Genome Medicine
Shigeto Yamawaki Hiroshima University Graduate School of Biomedical Sciences Psychopharmacology

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